UAC is "User Account Control" In vista, you can get to this through the control panel. This is the thing where when you click on certain programs, a pop-up dialogue tells you that the program is trying to do x, but needs permission to do so. Usually, you just click "run anyways" or the "yes" button, and it runs like normal. For the sakray patchers, that pop-up never gets a chance to come up, so it just fails completely. Thus, you need to go to the control panel and turn that off.
Control Panel --> Security Settings --> "Other Security Settings" Drop-down menu --> Turn UAC off.
Try again, if it doesn't work, post again, and someone'll be able to help you.