Using the Wine API, it should work. You might get some other errors due to the nature of Wine and Linux, since RO is a pure Windows application, and Wine often crashes for no obvious reason. However, if you are using an ATI video card, RO will most likely not run smoothly, because Wine isn't able to switch to OpenGL/hardware mode (as far as I know, last time I tested, it didn't work), and it will always run in software mode (3D in software mode = very slow).