I wish I had the old thread of the animaRO forums saved where I went in and broke down exactly how much damage each of the "top choice" weapons would do against each type of monster in Skellington.
Overall winner in damage was indeed the +10 Two-Handed Axe[2], but you lose your ability to use a shield, so IMO it's not worth it. However, it is an option. I don't remember if it still was better at +9.
For one-handed weapons, the +10 Axe[4] is actually superior by a marginal amount over the competition. The +10 Chain[3] is actually worse than the +10 Mace[4]. At a maximum damage hit, the Chain has a total of +50 from upgrades, compared to the mace's +29 maximum, and there is a 47 base ATK difference between the two, netting a total difference, at a maximum, of (47+21) 68, which is only 3 points higher than the damage bonus the mace would get from having a 2nd Samurai card. Considering there is a random chance of getting anywhere from +1 to +20 damage from the Chain on any given hit, the maximum potential of the Chain[3] over the Mace[4] simply isn't consistent enough. It is cheaper, though.