i also find that it affects my dating chances with gypsys.... they see all that extra weight and lots of them say... nothx

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but on a serious note, the only thing it'll affect aside from HP/SP regen is that you'll probably have to empty out your inventory when you /if you reskill.
I know some players that go everywhere at 89%. I'm rather fond of natural sp regen when i'm PvM-ing, but it doesn't really bother me too much when i'm in WoE. Also as a heavy melee class i really like my natural hp/sp regen in PvP, it really depends on what you're doing and how much you wanna spend on GJ.